The Relationship Between Atherosclerosis and the Intima Media Thickness of Carotid Arteries With Serum C-Reactive Protein Levels in Patients With Systemic Lupus Erythematosus

AUTHORS

Zahra Zakeri 1 , Sharareh Saneie Sistani 2 , Zohre Bari 3 , Alireza Ansari-Moghaddam 3 , Mahmoud Imani 4 , Mohammad Reza Miradi 1 , Mahnaz Sandooghi 1 , *

1 Department of Internal Medicine, Ali-Ebne-Abitaleb Hospital, Zahedan University of Medical Sciences,, Zahedan, IR Iran

2 Department of Radiology, Ali-Ebne-Abitaleb Hospital, Zahedan University of Medical Sciences, , Zahedan, IR Iran

3 Health Promotion Research Center, Zahedan University of Medical Sciences,, Zahedan, IR Iran

4 Department of Pediatric, Ali-Ebne-Abitaleb Hospital, Zahedan University of Medical Sciences, , Zahedan, IR Iran

How to Cite: Zakeri Z, Saneie Sistani S, Bari Z, Ansari-Moghaddam A, Imani M, et al. The Relationship Between Atherosclerosis and the Intima Media Thickness of Carotid Arteries With Serum C-Reactive Protein Levels in Patients With Systemic Lupus Erythematosus, Health Scope. 2012 ; 1(2):e93532. doi: 10.5812/jhs.6820.

ARTICLE INFORMATION

Health Scope: 1 (2); e93532
Published Online: August 07, 2012
Article Type: Research Article
Received: May 13, 2019
Accepted: June 26, 2012
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Abstract

Background: Patients with systemic lupus erythematous (SLE) are more prone to atherosclerosis and cardiovascular diseases due to atherosclerosis and consequently death.

Objectives: The aim of this study was to explore a possible relationship between the intima media thickness (IMT) of carotid arteries and the levels of C-reactive protein (CRP) in SLE patients.

Patients and Methods:: Sixty SLE patients and 60 healthy persons, being matched in age, ethnicity, gender and body mass index, were recruited for the study. The thickness of intima-media of the carotid arteries and the levels of CRP were measured using color Doppler ultrasonography and highly sensitive CRP measurement methods, respectively then findings were compared between the two groups.

Results:: Ultrasonographic evaluation showed atherosclerosis in 6 (10%) and 3 persons (5%) of the patients and control groups, respectively (P = 0. 298). The mean thickness of intima-media was not significantly different between the two groups (P = 0.31).But the mean level of CRP was significantly higher in patients group (P = 0. 005).

Conclusions:: We could not find any relationship between the serum CRP level and the risk of atherosclerosis progression in patients with SLE. Perhaps, SLE alone is not an independentrisk factor for atherosclerosis.

Keywords

Systemic Lupus Erythematosus Carotid Intima-Media Thickness Atherosclerosis C - Reactive Protein

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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