Health Scope

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Effect of L-Carnitine Supplementation on Metabolic Status in Obese Diabetic Women With Hypocaloric Diet

Beitullah Alipour 1 , Ali Barzegar 1 , * , Farid Panahi 2 , Abdolrasol Safaeian 1 and Masoud Es.haghi 2
Authors Information
1 School of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
Article information
  • Health Scope: February 24, 2014, 3 (1); e14615
  • Published Online: February 17, 2014
  • Article Type: Research Article
  • Received: November 2, 2013
  • Revised: December 1, 2013
  • Accepted: December 10, 2013
  • DOI: 10.17795/jhealthscope-14615

To Cite: Alipour B, Barzegar A, Panahi F, Safaeian A, Es.haghi M. Effect of L-Carnitine Supplementation on Metabolic Status in Obese Diabetic Women With Hypocaloric Diet, Health Scope. 2014 ; 3(1):e14615. doi: 10.17795/jhealthscope-14615.

Copyright © 2014, Health Promotion Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Materials
4. Results
5. Discussion
  • 1. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health. Obes Res. 1998; 6 Suppl 2: 51S-209S[PubMed]
  • 2. Hollmann M, Runnebaum B, Gerhard I. Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women. Int J Obes Relat Metab Disord. 1997; 21(6): 476-83[PubMed]
  • 3. Motta M, Bennati E, Capri M, Ferlito L, Malaguarnera M. Diabetes mellitus in the extreme longevity. Exp Gerontol. 2008; 43(2): 102-5[DOI][PubMed]
  • 4. Fumelli P, Romagnoli F, Carlino G, Fumelli C, Boemi M. Diabetes mellitus and chronic heart failure. Arch Gerontol Geriatr. 1996; 23(3): 277-81[PubMed]
  • 5. Bottini N, Vang T, Cucca F, Mustelin T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin Immunol. 2006; 18(4): 207-13[DOI][PubMed]
  • 6. Warren RE. The stepwise approach to the management of type 2 diabetes. Diabetes Res Clin Pract. 2004; 65 Suppl 1-8[DOI][PubMed]
  • 7. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5): 1047-53[PubMed]
  • 8. Diabetes mellitus, Fact sheet N°138 and N°236. 1999;
  • 9. Canbakan B, Tahan V, Balci H, Hatemi I, Erer B, Ozbay G, et al. Leptin in nonalcoholic fatty liver disease. Ann Hepatol. 2008; 7(3): 249-54[PubMed]
  • 10. Riobó SP. Obesity and diabetes. Nutr hosp. 2013; 28 Suppl 5: 138-43
  • 11. Bremer J. The Role of Carnitine in Cell Metabolism. 1997; : 1[DOI]
  • 12. Cerretelli P, Marconi C. L-carnitine supplementation in humans. The effects on physical performance. Int J Sports Med. 1990; 11(1): 1-14[DOI][PubMed]
  • 13. Rebouche CJ, Chenard CA. Metabolic fate of dietary carnitine in human adults: identification and quantification of urinary and fecal metabolites. J Nutr. 1991; 121(4): 539-46[PubMed]
  • 14. Amat di San Filippo C, Taylor MR, Mestroni L, Botto LD, Longo N. Cardiomyopathy and carnitine deficiency. Mol Genet Metab. 2008; 94(2): 162-6[DOI][PubMed]
  • 15. Ramsay RR. The carnitine acyltransferases: modulators of acyl-CoA-dependent reactions. Biochem Soc Trans. 2000; 28(2): 182-6[PubMed]
  • 16. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 2003; 26(4): 1277-94[PubMed]
  • 17. Nakai N, Miyazaki Y, Sato Y, Oshida Y, Nagasaki M, Tanaka M, et al. Exercise training increases the activity of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats. Endocr J. 2002; 49(5): 547-54[PubMed]
  • 18. Sugden MC, Holness MJ. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Curr Drug Targets Immune Endocr Metabol Disord. 2002; 2(2): 151-65[PubMed]
  • 19. Huang B, Wu P, Popov KM, Harris RA. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Diabetes. 2003; 52(6): 1371-6[PubMed]
  • 20. De Palo E, Gatti R, Sicolo N, Padovan D, Vettor R, Federspil G. Plasma and urine free L-carnitine in human diabetes mellitus. Acta Diabetol Lat. 1981; 18(1): 91-5[PubMed]
  • 21. Tamamogullari N, Silig Y, Icagasioglu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. J Diabetes Complications. 1999; 13(5-6): 251-3[PubMed]
  • 22. Derosa G, Cicero AF, Gaddi A, Mugellini A, Ciccarelli L, Fogari R. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin Ther. 2003; 25(5): 1429-39[PubMed]
  • 23. Cuturic M, Abramson RK, Moran RR, Hardin JW. Carnitine and metabolic correlates in hospitalized psychiatric patients: a follow-through report. J Psychiatr Pract. 2011; 17(1): 35-40[DOI][PubMed]
  • 24. Haeckel R, Kaiser E, Oellerich M, Siliprandi N. Carnitine: metabolism, function and clinical application. J Clin Chem Clin Biochem. 1990; 28(5): 291-5[PubMed]
  • 25. Pekala J, Patkowska-Sokola B, Bodkowski R, Jamroz D, Nowakowski P, Lochynski S, et al. L-carnitine--metabolic functions and meaning in humans life. Curr Drug Metab. 2011; 12(7): 667-78[PubMed]
  • 26. Barzegar A, Alipour B, Panahi F, Karamzad N. Effect Of L-carnitine supplementation on serum adipokines (leptin and visfatin) levels in obese type ii diabetes mellitus women with hypocaloric diet. Life Sci J. 2013; 10(11s)
  • 27. Sirtori CR, Calabresi L, Ferrara S, Pazzucconi F, Bondioli A, Baldassarre D, et al. L-carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). Nutr Metab Cardiovasc Dis. 2000; 10(5): 247-51[PubMed]
  • 28. Casciani CU, Caruso U, Cravotto E, Corsi M, Pola P, Savi L, et al. EFFECT of l-carnitine on lipid pattern in haemodialysis. Lancet. 1980; 316(8207): 1309-10
  • 29. Gonzalez-Ortiz M, Hernandez-Gonzalez SO, Hernandez-Salazar E, Martinez-Abundis E. Effect of oral L-carnitine administration on insulin sensitivity and lipid profile in type 2 diabetes mellitus patients. Ann Nutr Metab. 2008; 52(4): 335-8[DOI][PubMed]
  • 30. El-Metwally TH, Hamed EA, Ahmad AR, Mohamed NA. Dyslipidemia, oxidative stress and cardiac dysfunction in children with chronic renal failure: effects of L-carnitine supplementation. Ann Saudi Med. 2003; 23(5): 270-7[PubMed]
  • 31. Rajasekar P, Anuradha CV. Effect of L-carnitine on skeletal muscle lipids and oxidative stress in rats fed high-fructose diet. Exp Diabetes Res. 2007; 2007: 72741[DOI][PubMed]
  • 32. Frayn KN. Insulin resistance, impaired postprandial lipid metabolism and abdominal obesity. A deadly triad. Med Princ Pract. 2002; 11 Suppl 2: 31-40[PubMed]
  • 33. Rao NK, Nammi S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2006; 6: 17[DOI][PubMed]
  • 34. Rubin MR, Volek JS, Gomez AL, Ratamess NA, French DN, Sharman MJ, et al. Safety measures of L-carnitine L-tartrate supplementation in healthy men. J Strength Cond Res. 2001; 15(4): 486-90[PubMed]
  • 35. Rebouche CJ. Is carnitine an essential nutrient for humans? J Nutr. 1986; 116(4): 704-6[PubMed]
  • 36. Goa KL, Brogden RN. l-Carnitine. A preliminary review of its pharmacokinetics, and its therapeutic use in ischaemic cardiac disease and primary and secondary carnitine deficiencies in relationship to its role in fatty acid metabolism. Drugs. 1987; 34(1): 1-24[PubMed]
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