Health Scope

Published by: Kowsar

Protective Effect of Microporous Natural Clinoptilolite on Lead-Induced Learning and Memory Impairment in Rats

Ahmad Nikpey 1 , * , Hossein Kazemian 2 , Ali Safari-Varyani 1 , Marjan Rezaie 3 and Majid Sirati-Sabet 4
Authors Information
1 Department of Occupational Health, Qazvin University of Medical Sciences, Qazvin, IR Iran
2 Department of Chemical and Biochemical Engineering, Faculty of Engineering, Western University (UWO), London, Ontario, Canada
3 Department of Occupational Health, Tehran University of Medical Sciences, Tehran, IR Iran
4 Department of Biochemistry and Genetic, Qazvin University of Medical Sciences, Qazvin, IR Iran
Article information
  • Health Scope: May 15, 2013, 2 (1); 52-57
  • Published Online: May 11, 2013
  • Article Type: Research Article
  • Received: December 30, 2012
  • Revised: March 6, 2013
  • Accepted: March 9, 2013
  • DOI: 10.17795/jhealthscope-10041

To Cite: Nikpey A, Kazemian H, Safari-Varyani A, Rezaie M, Sirati-Sabet M. Protective Effect of Microporous Natural Clinoptilolite on Lead-Induced Learning and Memory Impairment in Rats, Health Scope. 2013 ; 2(1):52-57. doi: 10.17795/jhealthscope-10041.

Copyright © 2013, Health Promotion Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Education M. A guide to lead control in work place. 2011; : 170
  • 2. Balali-Mood M, Shademanfar S, Rastegar Moghadam J, Afshari R, Namaei Ghassemi M, Allah Nemati H, et al. Occupational lead poisoning in workers of traditional tile factories in Mashhad, Northeast of Iran. Int J Occup Environ Med. 2010; 1(1): 29-38[PubMed]
  • 3. Braun V, Rath SA, Antoniadis G, Richter HP. In vivo experiences with frameless stereotactically guided screw placement in the spine--results from 75 consecutive cases. Neurosurg Rev. 2001; 24(2-3): 74-9[PubMed]
  • 4. Colella C. Use of Italian chabazite and philipsite for the removal of heavy metals from wastewater's: A review, in Natural zeolite' 93, (D.W. Ming and F.A. Mumpton, eds.), int. comm. natural zeolites. 1995;
  • 5. Nemsadze K, Sanikidze T, Ratiani L, Gabunia L, Sharashenidze T. Mechanisms of lead-induced poisoning. Georgian Med News. 2009; (172-173): 92-6[PubMed]
  • 6. Khan DA, Qayyum S, Saleem S, Khan FA. Lead-induced oxidative stress adversely affects health of the occupational workers. Toxicol Ind Health. 2008; 24(9): 611-8[DOI][PubMed]
  • 7. Patrick L. Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern Med Rev. 2006; 11(2): 114-27[PubMed]
  • 8. Jacob B, Ritz B, Heinrich J, Hoelscher B, Wichmann HE. The effect of low-level blood lead on hematologic parameters in children. Environ Res. 2000; 82(2): 150-9[DOI][PubMed]
  • 9. Freedman R, Olson L, Hoffer BJ. Toxic effects of lead on neuronal development and function. Environ Health Perspect. 1990; 89: 27-33[PubMed]
  • 10. Wang XM, Liu WJ, Zhang R, Zhou YK. Effects of exposure to low-level lead on spatial learning and memory and the expression of mGluR1, NMDA receptor in different developmental stages of rats. Toxicol Ind Health. 2012; [DOI][PubMed]
  • 11. Li ZY, Yan CH, Xu J, Huang H, Zou XY. [Effects of prenatal exposure to stress and lead on spatial learning and memory development in rats]. Zhonghua Yu Fang Yi Xue Za Zhi. 2008; 42(10): 717-21[PubMed]
  • 12. Hoshmand F, A H, Fesharakie F. Spectral changes in brain waves and learning and memory dysfunction associated with low levels of lead exposure during fetal rat. Lorestan Uni Med Sci. 2003; 19
  • 13. Bidaran SNS. The Effect of Low Concentration of Lead Acetate on Learning Ability and Memory of Rats during Infancy and Adulthood. Armagan Danesh. 2010; 15(1): 47-55
  • 14. Fan G, Feng C, Li Y, Wang C, Yan J, Li W, et al. Selection of nutrients for prevention or amelioration of lead-induced learning and memory impairment in rats. Ann Occup Hyg. 2009; 53(4): 341-51[DOI][PubMed]
  • 15. Khan DA, Ansari WM, Khan FA. Synergistic effects of iron deficiency and lead exposure on blood lead levels in children. World J Pediatr. 2011; 7(2): 150-4[DOI][PubMed]
  • 16. D'Souza HS, Menezes G, Venkatesh T. Role of essential trace minerals on the absorption of heavy metals with special reference to lead. Indian J Clin Biochem. 2003; 18(2): 154-60[DOI][PubMed]
  • 17. Satija NK, Vij AG. Preventive action of zinc against lead toxicity. Indian J Physiol Pharmacol. 1995; 39(4): 377-82[PubMed]
  • 18. H FHaK. Effect of different parameters on the uptake of Pb, Ag, Ni, Cd, and Zn in natural clinoptilolite. Asian Chem. 1999; 3(4): 279-283
  • 19. Dyer A, Morgan S, Wells P, Williams C. The use of zeolites as slow release anthelmintic carriers. J Helminthol. 2000; 74(2): 137-41[PubMed]
  • 20. Hayakawa KMY, Maeda T, Satake I, Sato M. Surfactant-modified zeolites as a drug carrier and the release of chloroquin Prog. Colloid Polym Sci. 2000; 278: 553-558
  • 21. Kececi T, Oguz H, Kurtoglu V, Demet O. Effects of polyvinylpolypyrrolidone, synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis. Br Poult Sci. 1998; 39(3): 452-8[DOI][PubMed]
  • 22. Prvulović D.J, Stanić B, Popović M, Grubor-Lajšić G. Effects of a clinoptilolite supplement in pig diets on performance and serum parameters. Czech J Anim Sci. 2007; 52(6): 159-164
  • 23. Brown S, Dragann N, Vogel WH. Effects of lead acetate on learning and memory in rats. Arch Environ Health. 1971; 22(3): 370-2[PubMed]
  • 24. Ma T, Chen HH, Ho IK. Effects of chronic lead (Pb) exposure on neurobehavioral function and dopaminergic neurotransmitter receptors in rats. Toxicol Lett. 1999; 105(2): 111-21[PubMed]
  • 25. Rahman A, Khan KM, Al-Khaledi G, Khan I, Al-Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012; 33(3): 370-83[DOI][PubMed]
  • 26. Barrowcliffe TW, Edwards SJ, Gray E, Kerry PJ. Procoagulant activity of platelet arachidonic acid metabolites. Br J Pharmacol. 1987; 92(1): 129-32[PubMed]
  • 27. Öztürk E, Erenler G, Sarıca M. Influence of natural zeolite on performance of laying hens and egg quality. Turkish J Agric Forestry. 1998; 22: 623-628
  • 28. Nakaue HS, Koellike JK, Pierson ML. Studies with clinoptilolite in Poultry. 2. Effect of feeding broilers and the direct application of clinoptilolite (zeolite) on clean and re-used broiler performance and houses environment. Poult Sci. 1981; 60: 1221-1225
  • 29. Roland DA, Sr, Laurent SM, Orloff HD. Shell quality as influenced by zeolite with high ion-exchange capability. Poult Sci. 1985; 64(6): 1177-87[PubMed]
  • 30. Başalan M, Güngör T, Aydoğan I, Hışmıoğulları S.E, Erat S, Erdem E. Effects of adding HSCAS to broiler diets prior to slaughter on performance, digestive system pH's and blood biochemistry., in National Animal Nutrition Congress III, Adana. 2005; : 374-377
  • 31. Dwyer MR, Kubena LF, Harvey RB, Mayura K, Sarr AB, Buckley S, et al. Effects of inorganic adsorbents and cyclopiazonic acid in broiler chickens. Poult Sci. 1997; 76(8): 1141-9[PubMed]
  • 32. Miles RDHPR. Safety of improved Milbond-TX® when fed in broilers diets at greater than recommended levels. Anim Feed Sci Technol. 2007; 138: 309-317
  • 33. Martin-Kleiner I, Flegar-Mestric Z, Zadro R, Breljak D, Stanovic Janda S, Stojkovic R, et al. The effect of the zeolite clinoptilolite on serum chemistry and hematopoiesis in mice. Food Chem Toxicol. 2001; 39(7): 717-27[PubMed]
  • 34. Eleroğlu H.Y.H, Yıldırım A. Dietary effects of Ca-zeolite supplementation on some blood and tibial bone characteristics of broilers. South Africa J Anim Sci. 2011; 41(4): 319-330
  • 35. Safaeikatouli M, Jafariahangari Y, Baharlouei A. An evaluation on the effects of dietary kaolin and zeolite on broilers blood parameters, T4, TSH and growth hormones. Pakistan J Nutr. 2011; 10: 233-237
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