Health Scope

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Health Risk Assessment of Heavy Metals in Vegetables in an Endemic Esophageal Cancer Region in Iran

Ali Zafarzadeh 1 , * , Hadi Rahimzadeh 1 and Amir Hossein Mahvi 2
Authors Information
1 Department of Environmental Health Engineering, Environmental Health Research Center, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
2 Tehran University of Medical Sciences, Environmental Health, Center for Solid Waste Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Health Scope: August 2018, 7 (3); e12340
  • Published Online: August 20, 2018
  • Article Type: Research Article
  • Received: April 30, 2017
  • Accepted: July 6, 2017
  • DOI: 10.5812/jhealthscope.12340

To Cite: Zafarzadeh A, Rahimzadeh H, Mahvi A H. Health Risk Assessment of Heavy Metals in Vegetables in an Endemic Esophageal Cancer Region in Iran, Health Scope. 2018 ; 7(3):e12340. doi: 10.5812/jhealthscope.12340.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Scheen AJ, Giet D. [Role of environment in complex diseases: air pollution and food contaminants]. Rev Med Liege. 2012;67(5-6):226-33. French. [PubMed: 22891472].
  • 2. Coduro E. [Chemical contaminants in food]. Zentral b Bacteriol Microbiol Hyg B. 1986;183(2-3):221-33. German.
  • 3. Zukowska J, Biziuk M. Methodological evaluation of method for dietary heavy metal intake. J Food Sci. 2008;73(2):R21-9. doi: 10.1111/j.1750-3841.2007.00648.x. [PubMed: 18298744].
  • 4. Mohseni-Bandpei A, Ashrafi SD, Kamani H, Paseban A. Contamination and ecological risk assessment of heavy metals in surface soils of Esfarayen City, Iran. Health Scope. 2016;Forthcoming.
  • 5. Zarei M, Eskandari MH, Pakfetrat S. Determination of heavy metals content of refined table salts. Am Eurasia J Toxic Sci. 1986;3(2):59-62.
  • 6. Inbaraj BS, Chen BH. In vitro removal of toxic heavy metals by poly (γ-glutamic acid)-coated superparamagnetic nanoparticles. Int j nanomed. 2012;7:4419.
  • 7. Zafarzadeh A, Mehdinejad M. [Accumulation of heavy metals in agricultural soil irrigated by sewage sludge and industrial effluent (case study: Agh ghallah industrial estate)]. J Mazandaran Univ Med Sci. 2015;24(121):217-26. Persian.
  • 8. Trichopoulos D, Lipworth L, Petridou E, Adami HO. Epidemiology of cancer. In: DeVita VT, Hellman S, Rosenberg SA, editors. Cancer, principles and practice of oncology. Philadelphia: lippincott Company; 1986. p. 231-58.
  • 9. Hartwig A. Carcinogenicity of metal compounds: possible role of DNA repair inhibition. Toxicol Letters. 1998;102:235-9.
  • 10. Abdulla M, Chmielnicka J. New aspects on the distribution and metabolism of essential trace elements after dietary exposure to toxic metals. Biolog Trace Element Res. 1989;23(1):25-53. doi: 10.1007/bf02917176.
  • 11. Arora M, Kiran B, Rani S, Rani A, Kaur B, Mittal N. Heavy metal accumulation in vegetables irrigated with water from different sources. Food Chem. 2008;111(4):811-5. doi: 10.1016/j.foodchem.2008.04.049.
  • 12. Alam MGM, Snow ET, Tanaka A. Arsenic and heavy metal contamination of vegetables grown in Samta village, Bangladesh. Sci Total Environ. 2003;308(1-3):83-96. doi: 10.1016/s0048-9697(02)00651-4.
  • 13. Turkdogan MK, Kilicel F, Kara K, Tuncer I, Uygan I. Heavy metals in soil, vegetables and fruits in the endemic upper gastrointestinal cancer region of Turkey. Environ Toxicol Pharmacol. 2003;13(3):175-9. doi: 10.1016/s1382-6689(02)00156-4.
  • 14. Waalkes MP, Rehm S. Cadmium and prostate cancer. J Toxicol Environ Health. 1994;43(3):251-69. doi: 10.1080/15287399409531920. [PubMed: 7966437].
  • 15. Kamangar F, Malekzadeh R, Dawsey SM, Saeidi F. Esophageal cancer in Northeastern Iran: a review. Arch Iran Med. 2007;10(1):70-82.
  • 16. Hakami R, Mohtadinia J, Etemadi A, Kamangar F, Nemati M, Pourshams A, et al. Dietary intake of benzo(a)pyrene and risk of esophageal cancer in north of Iran. Nutr Cancer. 2008;60(2):216-21. doi: 10.1080/01635580701684831. [PubMed: 18444153].
  • 17. Morris Brown L, Hoover R, Silverman D, Baris D, Hayes R, Swanson GM, et al. Excess incidence of squamous cell esophageal cancer among US black men: role of social class and other risk factors. Am J Epidemiol. 2001;153(2):114-22. doi: 10.1093/aje/153.2.114.
  • 18. Sadjadi A, Marjani H, Semnani S, Nasseri-Moghaddam S. Esophageal cancer in Iran: a review. Middle East J Cancer. 2010;1(1):5-14.
  • 19. American Public Health Association. Standard methods for the examination of water and wastewater. 20th ed. Washington, D.C: APHA, Inc; 1986.
  • 20. Cui YJ, Zhu YG, Zhai RH, Chen DY, Huang YZ, Qiu Y, et al. Transfer of metals from soil to vegetables in an area near a smelter in Nanning, China. Environ Int. 2004;30(6):785-91. doi: 10.1016/j.envint.2004.01.003. [PubMed: 15120196].
  • 21. Institute of Standards and Industrial Research of Iran. Food & Feed - Maximum limit of heavy metals. 1st ed. ISIRI; 2013.
  • 22. Joint FAO/WHO Expert Committee on Food Additives . Summary and conclusions. The 53rd Meeting Joint FAO/WHO Expert Committee on Food Additives. Rome, Italy. 1999.
  • 23. Environmental Protection Agency. Users' guide and background technical document for USEPA region 9's preliminary remediation goals (PRG) table, PRG 2004 table. 2004. Available from:
  • 24. US Environmental Protection Agency. Exposure factors handbook general factors.EPA/600/p-95/002fa, vol. I. Office of research and development.National center for environmental assessment. Washington, DC: USEPA; 1997. Available from:
  • 25. Codex Alimentarius Commission. Position paper on cadmium. WHO food standards programme, ALINORM. 1994:CX/FAC 95/19.
  • 26. Codex Alimentarius Commission. Food additives and contaminants. joint FAO. WHO food standards programme, ALINORM. 2001;1:1-289.
  • 27. Chandorkar S, Deota P. Heavy metal content of foods and health risk assessment in the study population of Vadodara. Curr World Environ J. 2013;8(2):291-7. doi: 10.12944/cwe.8.2.15.
  • 28. Song B, Lei M, Chen T, Zheng Y, Xie Y, Li X, et al. Assessing the health risk of heavy metals in vegetables to the general population in Beijing, China. J Environ Sci. 2009;21(12):1702-9. doi: 10.1016/s1001-0742(08)62476-6.
  • 29. Ali MH, Al-Qahtani KM. Assessment of some heavy metals in vegetables, cereals and fruits in Saudi Arabian markets. Egypt J Aquatic Res. 2012;38(1):31-7. doi: 10.1016/j.ejar.2012.08.002.
  • 30. Sharma RK, Agrawal M, Marshall FM. Heavy metals in vegetables collected from production and market sites of a tropical urban area of India. Food Chem Toxicol. 2009;47(3):583-91. doi: 10.1016/j.fct.2008.12.016. [PubMed: 19138719].
  • 31. Radwan MA, Salama AK. Market basket survey for some heavy metals in Egyptian fruits and vegetables. Food Chem Toxicol. 2006;44(8):1273-8. doi: 10.1016/j.fct.2006.02.004. [PubMed: 16600459].
  • 32. Bandpei AM, Bay A, Zafarzadeh A, Hassanzadeh V. Bioaccumulation of heavy metals muscle of common carp fish (Cyprinus carpio L, 1758) from Ala gul and Alma gul wetlands of Golestan and consumption risk assessment. Int J Med Res Health Sci. 2016;5(11):267-73.
  • 33. Semnani S, Roshandel G, Zendehbad A, Keshtkar A, Rahimzadeh H, Abdolahi N, et al. Soils selenium level and esophageal cancer: an ecological study in a high risk area for esophageal cancer. J Trace Elem Med Biol. 2010;24(3):174-7. doi: 10.1016/j.jtemb.2010.03.002. [PubMed: 20569930].
  • 34. Wei B, Yang L. A review of heavy metal contaminations in urban soils, urban road dusts and agricultural soils from China. Microchem J. 2010;94(2):99-107. doi: 10.1016/j.microc.2009.09.014.
  • 35. Bhutto MA, Ahmed M, Parveen Z, Kaloi GMR. Determination of heavy and essential metals in different wheat varieties grown in three districts of Sindh (Pakistan). Int J Agri Biol. 2006;8(4):448-9.
  • 36. Chiroma TM, Abdulkarim BI, Kefas HM. The impact of pesticide application on heavy metal (Cd, Pb and Cu) levels in spinach. Leonardo Electron J Pract Technol. 2007;11:117-22.
  • 37. Bahemuka TE, Mubofu EB. Heavy metals in edible green vegetables grown along the sites of the Sinza and Msimbazi rivers in Dar es Salaam, Tanzania. Food Chem. 1999;66(1):63-6. doi: 10.1016/s0308-8146(98)00213-1.
  • 38. Hu X, Jin W, Lv W, Cheng S, Jiang Y. Investigation and evaluation on heavy metal copper and cadmium contaminations of vegetables grown in Huanggangcity of China. Adv J Food Sci Technol. 2013;5(2):106-9. doi: 10.19026/ajfst.5.3227.
  • 39. Lacatusu R, Lacatusu AR. Vegetable and fruits quality within heavy metals polluted areas in Romania. Carpathian J Earth Environ Sci. 2008;3(2):115-29.
  • 40. Elbagermi MA, Edwards HGM, Alajtal AI. Monitoring of heavy metal content in fruits and vegetables collected from production and market sites in the Misurata area of Libya. Analytic Chem. 2012;2012:1-5. doi: 10.5402/2012/827645.
  • 41. Hariprasad NV, Dayananda HS. Environmental impact due to agricultural runoff containing heavy metals-a review. Int J Sci Res Public. 2013;3(5):224-80.
  • 42. Liu J, Zhang XH, Tran H, Wang DQ, Zhu YN. Heavy metal contamination and risk assessment in water, paddy soil, and rice around an electroplating plant. Environ Sci Pollut Res Int. 2011;18(9):1623-32. doi: 10.1007/s11356-011-0523-3. [PubMed: 21611830].
  • 43. Naghipour D, Amouei A, Nazmara S. A comparative evaluation of heavy metals in the different breads in iran: a case study of Rasht city. Health Scope. 2014;3(4). doi: 10.17795/jhealthscope-18175.
  • 44. Singh A, Sharma RK, Agrawal M, Marshall FM. Health risk assessment of heavy metals via dietary intake of foodstuffs from the wastewater irrigated site of a dry tropical area of India. Food Chem Toxicol. 2010;48(2):611-9. doi: 10.1016/j.fct.2009.11.041. [PubMed: 19941927].
  • 45. Hellstrom L, Persson B, Brudin L, Grawe KP, Oborn I, Jarup L. Cadmium exposure pathways in a population living near a battery plant. Sci Total Environ. 2007;373(2-3):447-55. doi: 10.1016/j.scitotenv.2006.11.028. [PubMed: 17222449].
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